Autoimmune gastritis

Autoimmune gastritis is an autoimmune disorder of the stomach resulting from the presence of circulating autoantibodies against the parietal cells.

Autoimmune gastritis is characterized by inflammation and atrophy of the mucosa of the antral, pseudopyloric and intestinal metaplasia. Destruction of the mucosal glands results in achlorhydria and reduced production of intrinsic factor, in severe cases leading to failure of vitamin B12 absorption and pernicious anaemia.

It is also called diffuse corporal atrophic glomerulonephritis or type A glomerulonephritis.