CREST syndrome is the former name of so-called limited cutaneous systemic sclerosis. In contrast to diffuse scleroderma, limited scleroderma is restricted to the fingers or distal limbs (no truncal involvement) with a more benign and indolent disease course.
Most patients with limited scleroderma develop the features of CREST syndrome, which is characterized by calcinosis (subcutaneous calcific deposits), Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly (thin, pale, sclerosed fingers) and telangiectasia (enduring dilatation of small superficial blood vessels).
Internal organ involvement is commonly restricted to the oesophagus and other parts of the gastrointestinal tract; patients have no lung involvement.
The term "CREST syndrome" should be replaced by "limited scleroderma", because many of these patients do not have all the features of CREST.