Miscellaneous

Anti-IgA | Sperm antibodies@@@@   

Anti-IgA

NEW!

Products

Article No.

No. of tests

EliA Anti-IgA 14-5535-01 2x12

 

Antigen

Purified human IgA

Promotion material

Flyer on EliA Anti-IgA (pdf)

Disease association and antibody prevalence

  • 40% of patients with selective IgA deficiency
  • 10-25% of patients with common variable immunodeficiency (CVID)
Selective IgA deficiency is most common in coeliac disease, while CVID is the most common symptomatic primary immunodeficiency (prevalence ~0.004%) characterized by low serum levels of IgG, IgA and variably IgM.   

Prevent anaphylactoid reactions

Immunoglobulin G (IgG) replacement therapy represents effective prophylaxis for infections in CVID patients. However, traces of IgA (0.05-6.0 mg/dl depending on the product) can be found in any given IgG product. Patients with anti-IgA antibodies are therefore at risk of developing an anaphylactoid reaction to these IgG formulations, especially upon intravenous administration. The frequency of transfusion reactions is approximately 1 in 30,000 in the general population, while it is as high as 1 in 30 in IgA deficiency. 

When is the measurement recommended?

  1. Mandatory:
    Patients who have IgA deficiency and are destined for blood transfusion or IgG replacement therapy.
  2. Recommended:
    Coeliac disease patients who are IgA-deficient, to assess the future risk in blood transfusions.
  3. Useful:
    Any IgA-deficient patient, to assess the future risk in blood transfusions.

Antibody isotype

IgG

References

Thon (2010)  |  Yuan S and Goldfinger D (2008)  |  Kumar V et al (2002)  |  Horn J et al (2006)  |  Lilic D and Sewell WAC (2008)  |  Brown R et al (2008  

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Sperm antibodies

Products

Article No.

No. of tests

Varelisa Sperm Antibodies 1 44 96 96

 

Antigen

Human sperm surface proteins purified 

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