Broad informative patterns – Go broad. Narrow down.

Thanks to the cross-reacting proteins, ImmunoCAP ISAC can give you information on hundreds of allergen sources in addition to the 51 sources the proteins are derived from.

Storage protein

• Proteins stable to heat and digestion; also causing reactions to cooked foods.
• Often associated with systemic and more severe reactions in addition to OAS.
• Proteins found in nuts and seeds serving as source material during the growth of a new plant.

LTP (non-specific Lipid Transfer Protein, nsLTP)

• Proteins stable to heat and digestion; also causing reactions to cooked foods.
• Often associated with systemic and more severe reactions in addition to OAS.
• Associated with allergic reactions to fruit and vegetables, especially in regions where peaches and closely related fruits are cultivated.

PR-10 protein, Bet v 1 homologue

• Most PR-10 proteins are sensitive to heat and digestion; cooked foods are often tolerated.
• Often associated with local symptoms such as oral allergy syndrome (OAS).
• Associated with allergic reactions to pollens, fruits and vegetables.

Profilin

• Proteins sensitive to heat and digestion; cooked foods are often tolerated.
• Seldom associated with clinical symptoms, but may cause local and even severe reactions in some patients.
• Profilins are present in all pollen and plant foods.

CCD

• A marker for sensitization to cross-reactive carbohydrate determinants.
• Rarely causes allergic reactions, but may produce positive in vitro test results to CCD-containing allergens from pollen, plant foods, insects and venoms.

Tropomyosin

• Proteins stable to heat and digestion; also causing reactions to cooked foods.
• As food allergens, often associated with systemic and more severe reactions in addition to OAS.
• Actin-binding proteins in muscle fibres, and a marker for cross-reactivity between crustaceans, mites and cockroach.

Parvalbumin

• Proteins stable to heat and digestion; also causing reactions to cooked foods.
• Often associated with systemic and more severe reactions in addition to OAS.
• Major allergens in fish, and a marker for cross-reactivity among different species of fish and amphibians.

Serum albumin

• Proteins fairly sensitive to heat and digestion.
• Proteins present in various biological fluids and solids in all animals, e.g. cow’s milk, blood, beef and epithelia.
• Cross-reactions between albumins from different mammalian species are well known, for example between cat and dog, and cat and pig (pork).