Goodpasture's Syndrome

Goodpasture's syndrome, a disease of unknown origin, is characterized by the triad of pulmonary hemorrhage, glomerulonephritis, and circulating antibody to basement membrane antigens. Intrapulmonary hemorrhage may be insignificant or may be severe and life-threatening, often preceding renal involvement by 1-12 months. Renal involvement is commonly rapidly progressive, with oliguric renal failure occurring within weeks to months of the clinical onset of the disease. Without early treatment, permanent renal failure is the rule.