ANCA-associated Vasculits

ANCA-associated vasculitis is characterized by inflammation and lesion of the small blood vessels.

They are a heterogeneous group with different preferences of organ involvement. Anti-Neutrophil Cytoplasmic Antibodies (ANCA) against neutrophil proteinase 3 and myeloperoxidase occur often in these diseases.
ANCA-associated vasculitides are comprised of granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis), microscopic polyangiitis (MPA) and Churg-Strauss syndrome, now also referred to by its medically more accurate term eosinophilic granulomatosis with polyangiitis (EGPA).

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.