This condition occurs in patients with asthma or a history of allergy. It usually develops in middle age and affects men more commonly than women.
In many patients, the disease follows a phasic pattern. Initially, an increase in allergic manifestations occurs, especially asthma, followed by eosinophilia and finally vasculitis. Fever, malaise, and weight loss are common early manifestations. As the vasculitis develops, asthma may become less prominent.
Cutaneous findings include petechiae, purpura, or ulcerations. Chest dicomfort or shortness of breath may result from pulmonary lesions. Peripheral neuropathy, usually multiple mononeuropathies, is common.
Abdominal symptoms include diarrhea pain, or a mass due to ischemia or infarction of abdominal organs. Renal lesions tend to be less severe than in Polyarteritis nodosa. Eosinophilic granulomatous involvement of the gastrointestinal and urinary tracts or prostate is a unique feature of this syndrome.