Rabbit

 
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Code: f213
Latin name: Oryctolagus spp.
Source material: Raw meat
Family: Leporidae
In general, the larger the number of atopic problems in an individual, the greater the chances of food being involved.

Allergen Exposure

Rabbits are found on all continents. Although relatively infrequent, meat allergy can be a serious problem for children both because it is generally associated with intolerance to other protein sources and because of the suggested role of meat in stimulating the gastrointestinal development during weaning (1).

Potential Cross-Reactivity

In a study of 12 children who had had clinical reactions after ingestion of bovine meat, Restani et al. (2) showed, that serum albumin seems to be the main or one of the most important antigens of bovine meat. This could suggest that other animal species such as rabbit be considered in the diet of atopic children. Serum albumin from rabbit was less frequently involved in the formation of binding with specific circulating IgE and in SPT responses.

Clinical Experience

Watt AD et al. (3) have reported on anaphylaxis to rabbit serum protein. A research physician accidently received a minor wound from a needle that had been previously used in rabbit tissue and within 15 minutes a serious anapylactic reaction started. The authors contend that this anaphylactic reaction was due to a response mediated by IgE by trace amounts of rabbit serum proteins accidently introduced into the superficial layers of the skin.
 
Review
Rabbits are found on all continents. Although relatively infrequent, meat allergy can be a serious problem for children both because it is generally associated with intolerance to other protein sources and because of the suggested role of meat in stimulating the gastrointestinal development during weaning (1). In a study of 12 children who had had clinical reactions after ingestion of bovine meat, Restani et al. (2) showed that serum albumin seems to be the main or one of the most important antigens of bovine meat. This could suggest that other animal species such as rabbit to be considered in the diet of atopic children. Serum albumin from rabbit was less frequently involved in the formation of binding with specific circulating IgE and in SPT responses. Data on cross-reactivity between meat of different animal species are useful to improve the basic knowledge of meat allergy and could contribute to solving the dietetic and clinical problems of atopic children. Watt AD et al. (3) have reported on anaphylaxis to rabbit serum protein. A research physician accidently received a minor wound from a needle that had been previously used in rabbit tissue and within 15 minutes a serious anapylactic reaction started. The authors contend that this anaphylactic reaction was due to a response mediated by IgE by trace amounts of rabbit serum proteins accidently introduced into the superficial layers of the skin.

References

  1. Johnson LR. Regulation of the gastrointestinal growth. In: Makhlouf GM, (ed); "Physiology of the Gastrointestinal Tract 2nd ed." New York: Raven Press 1987;301-33.
  2. Restani P, Fiocchi A, Beretta B, Velonà T, Giovannini M, Galli CL. Meat Allergy: III-proteins involved and cross-reactivity between different animal species. J Am College of Nutrition 1997;16(4):383-9.
  3. Watt AD, Mc Sharry CP. Laboratory animal allergy: anaphylaxis from a needle injury. Occupational and Environmental Medicine 1996;53:573-4.

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.