Ketamine


Incidence
Exceedingly rare.
 
Clinical manifestations
General: anaphylactic shock.
 
Cutaneous: rash, urticaria.
 
Respiratory: laryngospasm.
 
Diagnostic methods
Cutaneous testing

 
Intradermal skin-tests: 0.05 ml of Ketalar 5% or ketamine base 1/100 and 1/10 positive in one patient.
 
Mechanisms
Probable IgE-mediated hypersensitivity.
 
Management
Avoidance.
 

References

  1. Karayan J, Lacoste L, Breuil K, "Allergie à la kétamine", Ann.Fr.Anesth.Reanim., 1990 ; 9 (4): 396-7
  2. Mathieu A, Goudsouzian N, Swider M.T, "Reaction to ketamine: anaphylactoid or anaphylactic? " Br. J. Anaesth., 1975 ; 47: 624-7

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.