Short-acting general anesthetic used especially for tooth extractions.
Very high: 1 out of 500 to 1 out of 700 anesthesias.
Severe reactions: 0.007% to 0.13%.
General: anaphylactic shock.
Dermatological: various delayed reactions.
Digestive: nausea, vomiting, diarrhea.
Complement assay at the time of the accident (difficult).
Blood histamine measurement at the time of the accident.
Responsibility of solvent: cremophor E.L., which activates the classical or alternative complement pathway, releasing C3a anaphylatoxin and leukocyte migration.
Non-specific histamine release.
Prohibited in many countries since 1983.