Major morphinomimetic analgesic, used exclusively in anesthesia.
Previous sensitization to another phenylpiperidine drug.
General: anaphylactic shock.
Cutaneous: urticaria, angioedema, diffuse rash (transdermal fentanyl).
Intradermal skin-tests positive from 0.5 ng/ml to 5 ng/ml (2 cases reported).
Fentanyl does not induce non-specific histamine-release.
IgE-mediated hypersensitivity (positive skin-tests).