Narcotic analgesic frequently used for analgesia and general anesthesia (induction).
General: anaphylactic shock.
Cutaneous: flush, urticaria.
Respiratory: cough, wheezing.
Specific IgE (RAST): positive in a few cases of anaphylaxis.
Immediate skin-tests may be positive (do not exceed a concentration of 1/100000).
Non-specific histamine release (meperidine is one of the strongest histamine-releasers of all anaesthetic agents).