Mannitol is a hexahydric alcohol closely related to the hexose sugars ; which has been used in a variety of clinical situations for its osmotic diuretic qualities (chemotherapy, cerebral edema).
Very low. Fewer than 10 cases reported.
General: anaphylactic shock.
Cutaneous: urticaria, rash, pruritus, periorbital edema.
Respiratory: sneezing, bronchospasm, chest tightness.
Intradermal skin-tests positive at 1/100.
No specific IgE.
Specific histamine-release (RIA method) positive in a patient with anaphylactic shock.
Hyperosmolar solutes are capable of inducing non-cytotoxic basophil histamine release.
IgE-mediated hypersensitivity: positive cutaneous tests, specific histamine-release.