Itraconazole


Triazole antifungal agent used for treatment of histoplasmosis, coccidiodomycosis, paracoccidiodomycosis, sporotrichosis, candidosis and aspergillosis.
 
Incidence
Probably low.
 
Clinical manifestations
Erythematous rash.
 
Maculopapular rash.
 
Diagnostic methods
Skin-prick tests: negative.
 
Drug re-challenge.
 
Mechanisms
Unknown.
 
Management
Desensitization.
 
1 mg to 200 mg over 4 hours.

References

  1. Douglas R, Spelman D, Czarny D, O’Hehir R, "Desensitization to itraconazole (letter, comment)", J. Allergy. Clin. Immunol., 1997 ; 99 (2): 269
  2. Bittleman D.B, Stapleton J, Casale T.B, "Report of successful desensitization to itraconazole (see comments)", J. Allergy. Clin. Immunol, 1994 ; 94 (2.1): 270-1

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.