Nitroimidazole derivative used for the treatment of anaerobic infections and trichomonas infections.
Fever, serum sickness.
Urticaria, maculopapular rash, fixed drug eruption, pustulosis.
1.5 mg of 0.75% metronidazole vaginal gel applied to the vaginal mucosa induced wheals of 6 x 6 mm in one patient and 2.5 x 5 mm in another with severe allergic reactions to metronidazole.
IgE-mediated hypersensitivity is likely in some cases.
Cross-reactivity between metronidazole and tinidazole (fixed drug eruption).
Two different protocols have been published:
- 0.0025 mg to 1 000 mg in 8 steps (orally)
- 5 µg to 125 mg intravenously (3h40), then 250 mg, 500 mg, 2 g orally (3 h).