Praziquantel


Praziquantel is an isoquinolin drug widely used as trematodicide.
 
Incidence
Exceptional (one case published).
 
Risk factors
Unknown.
 
Clinical manifestations
Urticaria.
 
Difficulty swallowing.
 
Tightness of the chest.
 
Diagnostic methods
None.
 
Mechanisms
Unknown.
 
Management
Desensitization.
 
Premedication with hydroxyzine, dexamethasone and prednisone 6 hours prior to administration of praziquantel: 18 mg x 6 then 180 mg x 3, then 360 mg x 3 (at 15 minute intervals).

References

  1. Huang S.W, "A clinical approach to a patient with praziquantel hypersensitivity", J. Allergy. Clin. Immunol., 1992 ; 90: 5-867

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.