Semi-synthetic antibiotic derived from Rifamycin B.
Widely used by surgeons for local application.
Intradermal tests 50 µg/ml to 5000 µg/ml (positive in 4/4 patients with anaphylaxis).
Specific IgE: detected in at least one case.
Histamine release (positive in 2/3 patients with anaphylaxis).
Antiparasite cytotoxicity by platelets (positive in 4/4 patients with anaphylaxis).
Possible cross-reactivity with Rifampicine and Rifabutine.