Pyrimidine analogue used for the treatment of several types of malignancies. Topical 5-FU is widely used for the treatment of actinic keratosis and warts in some countries.
Seborrheic dermatitis (palmar-plantar dermatitis).
Iterative long-term topical applications.
Anaphylactic shock (4 cases reported).
Contact eczema by topical application, pigmentation abnormalities, phototoxicity and photosensitization.
Cutaneous testing: one case with intradermal test positive (anaphylactic shock).
Patch-tests and photopatch-tests with 0.5-1% 5-FU in pet.
No specific IgE found.
IgE-mediated hypersensitivity (one case of anaphylactic shock).
Probable direct cytotoxic effect of 5 FU (palmar-plantar dermatitis).