Antimitotic alkylating agent known as nitrogen mustard administered intravenously in the treatment of hematological disorders and applied topically in the treatment of mycosis fungoids and severe psoriasis.
Frequent when applied topically.
Uncommon when administered intravenously.
General: anaphylactic shock.
Cutaneous: pruritus, urticaria, angioedema, bullous reactions, contact dermatitis (topical use), erythema multiforme.
Cutaneous testing: prick-tests and patch-tests positive in patients with reactions to topical mechlorethamine.
Unknown for immediate reactions.
Cell-mediated hypersensitivity for contact dermatitis.
Desensitization in patients with mycosis fungoids.
- Topical desensitization: from 0.01 mg/100 ml to 20 mg/100 ml
- Intravenous desensitization.
Not always successful.