Granisetron, ondansetron and tropisetron are used for prevention of nausea and vomiting associated with cancer chemotherapy.
Ondansetron: 24 cases (FDA 1994).
Tropisetron: 11 cases.
Previous reaction with another 5 HT 3 receptor antagonist.
Differentiate from non-allergic side-effects (headache, gastrointestinal symptoms).
Rashes, Facial edema.
Drug re-challenge: positive.
Avoidance of all 5 HT 3 receptor antagonists due to effects of drug class.