Daunorubicin


Antimitotic antibiotic used to treat hematological disorders.
 
Incidence
Uncommon (1 to 2%).
 
No deaths reported.
 
Clinical manifestations
General: fever; anaphylactic shock.
 
Cutaneous: rash; urticaria, angioedema.
 
Diagnostic methods
No in vivo or in vitro method is currently available for diagnosis.
 
Mechanisms
Unknown.
 
Management
Avoidance.
 
Possible cross reactivity with doxorubicin.

References

  1. Ma D, Isbister J.P, "Cytotoxic-induced fulminant hyperpyrexia", Cancer, 1980; 45: 2249–51.
  2. Crowther D, Powles R.L, Bateman C.J.T, Beard M.E.J, Gauchi C.L, Wrigley P.F.M, Malpas J.S, Hamilton-Fairley G, Bodley-Scott R., "Management of adult acute myelogenous leukaemia", Br. Med. J., 1973; 1: 131–7.
  3. Freeman A.I, "Clinical note: allergic reaction to daunomycin (NSC-82151)", Cancer. Chemother. Rep., 1970; 54: 475-6

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.