Cytostatic agent produced by a strain of Streptomyces verticillus. Bleomycin inhibits cell cleavage by blocking the uptake of thymidine by DNA and leading to weakening and break-up of DNA chains.
Fever: 20 to 25% of patients.
Fulminant reactions: 1 to 8% of patients.
Lymphoma (for fulminant reactions).
General: fever, hypotension.
Cutaneous: pruritus, flagellate dermatitis, angioedema, toxic epidermal necrolysis, erythematous rash.
Respiratory: eosinophilic pneumonia, fibrosis.
No in vivo or in vitro method is currently available for diagnosis.
Non immunological mechanisms are likely.
Antihistamines and corticosteroids are sometimes effective.