Busulfan


Alkylating agent able to act selectively against the myeloid cell line used in the treatment of chronic leukemia, polycythemia vera, and thrombocythemia.
 
Incidence
Uncommon.
 
Clinical manifestations
Cutaneous (main manifestations): bullous eruptions, urticaria.
 
Respiratory: interstitial pneumonia (often severe), pulmonary fibrosis.
 
Diagnostic methods
No in vivo or in vitro method is currently available for diagnosis.
 
Mechanisms
Undetermined.
 
Management
Avoidance.

References

  1. Akoun G, Milleron B, Mayaud C, "Pulmonary changes caused by cytostatic drugs", Ann. Med. Interne.(Paris), 1985; 136 (8): 671-6
  2. Leyden M.J, Manoharan A, "Allopurinol-type" rash due to busulphan", Lancet., 1978; 2 (8093): 797

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.