Semi-synthetic derivative of podophyllotoxin, active against a number of tumors: germ cell neoplasms, small cell lung carcinoma and malignant lymphoma.
93 cases reported up to 1996.
High incidence in children with Hodgkin’s disease.
Hypotension, bronchospasm, facial flushing, exanthema, dyspnea, fever, chills, tachycardia, chest tightness, cyanosis, hypertension (rare).
Urticaria is uncommon.
No in vivo or in vitro method is currently available for diagnosis.
Non specific histamine release.
The role of polysorbate 80 (Tween 80) used as an excipient in the parenteral formulation is doubtful.
Lowering of the infusion rate.
Continuing administration without modification (65% successful)
Premedication with antihistamines and/ or corticosteroids.