Pentostatin (2'-deoxycoformycin) is an antibiotic produced by culture broths of Streptomyces antibioticus, and widely used as antineoplastic agent (lymphoid malignancies, mycosis fungoids, chronic lymphocytic leukemia).
0.5 to 1 %.
Concomitant use of allopurinol.
General: anaphylactic shock, fever.
Cutaneous: pruritus, rash, flushing, edema, dryness of the chest and limbs.
Respiratory: cough, pulmonary infiltrates.
Hypersensitivity vasculitis involving arteries and veins in the heart, spleen, cerebral cortex (autopsy).
Recurrence of reactions with drug re-challenge.
Concomitant administration of allopurinol to prevent hyperuricemia secondary to tumor lysis could enhance pentostatin toxicity.
Pentostatin is formulated using mannitol and sodium hydroxide.
Avoidance of systematic use of allopurinol.