Plant alkaloids frequently used in current chemotherapy protocols.
Exceptional for anaphylaxis.
More common for bronchospasm.
Associated treatment with mitomycin (respiratory manifestations).
General: anaphylactic shock (vincristine).
Cutaneous: erythrodermia, localized epidermal necrolysis
Respiratory: acute respiratory failure (vinblastine), bronchospasm, pleural effusion.
No in vivo or in vitro method is currently available for diagnosis. Pulmonary function tests show obstructive patterns.
Premedication with corticosteroids may be useful.