Furosemide or chloro-4-furfurylamino-2-sulfamoyl-5-benzoic acid is a widely used Henle’s loop diuretic.
Exceedingly rare for anaphylactic reactions.
0.5% for mild cutaneous reactions.
General: anaphylactic shock.
Cutaneous: pruritus, urticaria, periorbital edema, eczematous rash, vasculitis, lichenoid eruption, vesiculo-bullous eruption, Stevens Johnson’s syndrome.
Respiratory: acute pulmonary edema.
Digestive: pancreatitis, hepatitis.
Intradermal at 1%: positive for furosemide as well as for chlorothiazide, bumetanide and sulfamethoxazoletrimethoprim.
One case with delayed positivity (10th hour).
Type I suspected on a basis of immediate positive skin tests.
Type III suspected in pancreatitis and hepatitis.
No cross reactivity between furosemide and sulfonamides.
Bumetanide may be used as replacement therapy in furosemide induced vasculitis.