Carboxymethylcellulose sodium is a highly viscous material used in pharmaceutical preparations as a suspending agent to promote dissolution of compounds with poor water solubility (barium enema, corticosteroids).
Described with barium enema (differentiate from other ingredients: methylparaben, latex, carrageenan) and corticosteroids (cortivazol, prednisolone acetate, triamcinolone acetonide).
General: anaphylactic shock.
Cutaneous: pruritus, urticaria, angioedema.
Skin-prick tests: 1%.
Intradermal skin-tests: 1/100000 to 1/10000.
Scratch-tests: positive with the drug and carboxymethylcellulose.
Specific IgE: one case.
Specific histamine release: 2 cases.
Avoidance is extremely difficult due to the extensive use of carboxymethylcellulose (drugs and foods).