Povidone or polyvinyl pyrrolidone is a polymer with a molecular weight ranging from 10000 to 700000, comparable to plasma proteins and used as excipient in topical, oral, and parenteral pharmaceutical products.
General: anaphylactic shock
Cutaneous: urticaria, contact dermatitis.
Respiratory: asthma (hair spray).
Ocular: conjunctivitis (intraocular lenses).
Basophil degranulation test.
Histamine release test.
Non specific histamine release.
Povidone 10 has been shown to be a potent activator of suppressor T-cells, whereas povidone 40 and 60 are able to activate B-cells.