Tartrazine is an azo dye used in many foods an drugs including antibiotics, antihistamines, steroids, bronchodilators and antidepressants (imipramine, desipramine, amitriptyline).
0.1 to 6 subjects /1 000.
General: anaphylactic shock.
Cutaneous: urticaria (acute and chronic), angioedema, fixed drug eruption, contact dermatitis, allergic vasculitis.
The oral challenge with tartrazine is a only reliable method of accurate diagnosis:
Urticaria: tartrazine 1,5,25 and 50 mg at 30 minute intervals.
Asthma: tartrazine 0,1 mg to 50 mg at 30 minute intervals.
Direct histamine release?
Tartrazine free diet and avoidance of all drugs containing tartrazine. If symptoms improve, re-challenge with tartrazine. Reappearance of symptoms is sufficient proof of tartrazine hypersensitivity.
In obscure cases, perform oral challenge.
No cross reaction has been demonstrated between tartrazine and aspirin with regard to respiratory symptoms. Consequently, no avoidance of tartrazine in aspirin-allergic patients unless an adverse reaction has been observed in challenge tests.