Angiography using fluorescein is a valuable tool for the ophthalmologist in investigating vascular disease in general, and chorioretinitis in particular. However this useful method is not free from risk.
All adverse reactions: (IV administration): 0.6 to 16.1%.
(oral administration): 0.9%.
Flushing, itching, hives: 0.5 to 0.6%.
Anaphylaxis: 0 to 0.2% (deaths reported).
Previous reaction during fluorescein angiogram.
Black females (urticaria in one study).
General: anaphylactic shock
E.N.T.: sneezing (early symptom of allergy).
Cutaneous: pruritus, urticaria, angioedema.
False positive in intradermal skin-tests. A positive prick-test with 10% fluorescein solution could predict anaphylactoid reaction to intravenous injection of fluorescein.
No specific IgE found.
Non-specific histamine release?
Premedication may be useful (controversial).
Desensitization (0.1 ml 1/1 000 to 1 ml pure) is poorly used.