Indocyanine green

Used in the diagnosis and management of choroidal vasculature affections. Indocyanine green is a tricarbocyanine organic dye with less than 5% of iodine (for stabilization).
0.05% to 0.07%.
One death reported during cardiac catheterization with indocyanine green.
Clinical manifestations
Anaphylactic shock
Diagnostic methods
Anaphylaxis may be related to the iodine additive, or to the dye itself.


  1. Olsen T.W, Lim J.I, Capone A Jr, Myles R.A, Gilman J.P, "Anaphylactic shock following indocyanine green angiography (letter)", Arch. Ophtalmol., 1996; 114 (1): 97 
  2. Hope-Ross M, Yannuzzi L.A, Gradoudas E.S, "Adverse reactions due to indocyanine green", Ophtalmology., 1994; 101: 529-33 
  3. Obana A, Miki P, Hayashi K, "Survey of complications of indocyanine green angiography in Japan", Am. J. Ophtalmol., 1994; 118: 749-53 
  4. Wolf S, Arend O, Schulte K, Reim M, "Severe anaphylactic reaction after indocyanine green fluorescence angiography", Am. J. Ophtalmol., 1992; 114: 638-9 
  5. Benya R, Quintana J, Brundage B, "Adverse reactions to indocyanine green. A case report and review of the literature", Cathet. Cardiovasc. Diagn., 1989; 17: 231

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.