Gadolinium chelates used as contrast agents for magnetic resonance (MR) imaging are considered to be relatively safe.
Gadopentetate dimeglumine, gadoteridol, gadoterate meglumine.
Adverse reactions 2.4% (rash: 0.09%, urticaria: 0.07%, anaphylactic shock:3/million.
Adverse reactions in asthmatic patients: 3.7%.
Adverse reactions in allergic patients: 3.7%.
Adverse reactions in patients with a history of reaction to MR imaging contrast agent: 21.3%
Adverse reactions to iodinated contrast agent: 6.3%
Asthma, allergy, previous reaction to MR imaging contrast agent, previous reaction to iodinated contrast agent.
Rapid injection is not an adverse reaction risk factor.
Pruritus, facial and lingual edema, urticaria, maculopapular exanthema.
Paramagnetic contrast agents are ionic or non-ionic.
Although not yet fully understood, the same mechanisms as iodinated contrast agents could be involved.
No premedication data published.