Cacitonin is a 32 amino acid polypeptide synthesized by the parafollicular cells of the thyroid. It inhibits bone resorbtion and increases urinary calcium and phosphor output. Three types of calcitonin are used, i.e. natural porcine, synthetic salmon and synthetic human calcitonin, for the treatment of Paget’s disease, hypercalcemia, hyperparathyroidism, and osteoporosis.
Reported incidence varies from 6% to less than 1/30000.
General: anaphylactic shock.
Cutaneous: pruritus, rash, angioedema, urticaria.
Skin tests: scratch and intradermal (1/1000 and 1/100) were positive in one patient presenting anaphylactic shock with porcine calcitonin.
In vitro tests: detection of IgE against porcine calcitonin (RAST) was positive in one case.
Immediate IgE hypersensitivity.
Use other types of calcitonin (synthetic salmon or human calcitonin).
Negative skin-tests do not exclude allergic manifestations induced by calcitonin.