These drugs are used to induce ovulation and in treatment of endometriosis, polycystic ovary disease, precocious puberty, and prostate cancer.
Tripterolin, Gonadorelin, Buserelin, Leuprorelin (leuprolide), Nafarelin, Goserelin.
Local reactions: 0 to 13%.
General reactions are rare.
Route of administration (constant infusion > intermittent use).
Length of treatment.
General: anaphylactic shock.
Cutaneous: flush, pruritus, local erythema, urticaria, vasculitis (sometimes delayed)
Respiratory: sneeze, bronchospasm.
Skin-prick tests positive in various concentrations for gonadorelin, buserilin, goserilin, leuprorelin.
Specific IgE (RAST): a few cases published.
Specific IgG (RIA): controversial role.
MIF one case positive with triptorelin
Skin-biopsy: one case of allergic vasculitis with triptorelin.
IgE-mediated hypersensitivity (immediate positive skin tests, specific IgE).
Type III reaction (one case).
Non-specific histamine release.
Avoidance of all GnRHs.