BCG Vaccine is widely used throughout the world to prevent tuberculosis. Other indications are intralesional treatment in superficial bladder cancer.
Quite uncommon. Fewer than ten cases in neonates or infants have been reported.
Differentiate from lymphadenitis or generalized granulomatosis.
Lupus vulgaris +/- urticarial vasculitis.
Acute febrile neutrophilic dermatosis (Sweet’s syndrome).
Dextran reactive antibodies: in a few cases where high titers of DRA were found in a maternal blood sample or child’s blood sample.
Concerning the neonatal anaphylactic reactions reported after BCG vaccination, passively acquired maternal dextran antibodies reacted with the 100 KD dextran which is a component of the BCG vaccine.
Use BCG vaccine without dextran (sodium glutamate).
Dextran 1 should be used in the vaccines, instead of high molecular weight (100 KD) dextran.