Used as a plasma expander, in plasma exchange and for pulmonary perfusion scan (technetium 99 m labeled human albumin microspheres).
One third of reactions are life-threatening.
Intradermal skin tests with undiluted human serum albumin leads to false positive results.
Some authors reported positive skin tests with dialysed, undialyzed and ultracentrifuged HSA 0.5% and 5%.
Specific IgE (ELISA).
IgE-mediated hypersensitivity is suggested by immediately positive cutaneous tests and evidence of specific IgE.
Albumin aggregates (high molecular weight aggregates and some denatured albumin-globulin complexes may form during preparation of albumin solution).
IgG anti IgA in IgA-defective patients.