XII. Vitamines


Calcipotriol is a vitamin D3 derivative widely used in the treatment of psoriasis.
 
Incidence
High: 20% of patients.
 
Clinical manifestations
Lesional and perilesional irritation.
 
Contact allergy (underestimated).
 
Diagnostic methods
Patch-tests with the cream (ointment is irritant) or better with calcipotriol 10 µg/ml in isopropanol.
 
Patch-tests with propylene-glycol.
 
Mechanisms
Irritation.
 
Sometimes delayed contact hypersensitivity.
 
Management
Cream and solution are less irritant than ointment.
 
Avoidance in cases of contact allergy.
 
Cross-reactivity may exist between calcipotriol, 1-alpha-hydroxyvitamin D3 and 25-hydroxyvitamin D3.

References

  1. Giordano-Labadie F, Laplanche G, Bazex J, "Eczéma de contact au calcipotriol", Ann. Dermatol. Venereol., 1996; 123: 196-7
  2. de Groot A, "Contact allergy to calcipotriol", Contact. Dermatitis, 1994; 30: 242-3

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.