Specific H2 receptor antagonist, belonging to the group of imidazole derivatives. Used in the treatment of gastric and duodenal ulcers, gastroesophageal reflux and hypersecretory states.
One case reported.
General: anaphylactic shock
Respiratory: dyspnea, laryngeal stridor.
Cutaneous: urticaria, angioedema of lips and tongue.
Skin prick-tests: 10 mg/ ml: negative.
Intradermal skin tests: positive at 1/10000 to 1/1000.
Oral challenge test.
IgE-mediated hypersensitivity (positive skin tests, positive oral challenge).
No cross-reactivity found with other anti H2 drugs (oral challenge).