Recombinant human type I IL-1R receptor (rhu IL-1R)


Recombinant human type I IL-1 receptor is used to suppress inflammatory disorders.
 
Incidence
One report.
 
Clinical manifestations
Cutaneous: erythema, pruritus at the injection site within 15 minutes.
 
Diagnostic methods
Cutaneous testing.
 
Skin prick-tests: negative.
 
Intradermal skin-tests: 0.05 ml 500 µg/ml (25 µg): negative
 
0.05 ml 2500 µg/ml (125 µg): positive.
 
Specific IgE (ELISA): positive in one patient.
 
The specificity of antibodies is confirmed by inhibition ELISA studies.
 
Management
Avoidance.

References

  1. Grammer L.C, Roberts M, "Cutaneous allergy to recombinant human type I IL-1 receptor (rhu IL-1R)", J. Allergy. Clin. Immunol., 1997; 99 (5): 714-5

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.