Tetrazepam is a benzodiazepine with the general properties of diazepam, used as muscle relaxants (50 to 200 mg daily).
2/4767 recipients of benzodiazepine drugs.
Cutaneous: pruritus, urticaria, angioedema, general papular, maculopapular or purpuric rash, hand and face contact dermatitis (handling of the drug), erythema multiforme.
Respiratory: tightness of the chest.
Patch-tests with tetrazepam 1% aq or 1% and 5% pet.: positive in all cases.
Oral drug challenge.
Type IV hypersensitivity.
Avoidance of all benzodiazepines is not mandatory, since cross-reactivity is not always found in oral challenge tests.