Ubiquinone


Ubiquinone (coenzyme Q): 2-3 dimethoxy 5 methyl-6-decaphenyl benzoquinone is used in the treatment of mitochondrial myopathies and encephalomyopathies.
 
Incidence
3/2664 (rashes).
 
Clinical manifestations
Urticaria.
 
Diagnostic methods
Cutaneous testing.
 
Skin prick-tests: ubiquinone (5 mg/ ml): negative.
 
Patch-tests (15% in vaseline): negative.
 
Oral challenge tests: 5 mg, 10 mg, 15 mg, 20 mg: positive in one patient.
 
Mechanisms
Unknown.
 
Management
Desensitization (every 30 minutes).
 
Day 1: 0.25 mg, 050 mg, 1 mg, 2 mg
 
Day 2: 3.5 mg, 3.5 mg, 5 mg, 7.5 mg, 10 mg
 
Day 3: 10 mg, 12.5 mg, 15 mg,
 
Day 4: 15 mg, 17.5 mg, 17.5 mg.

References

  1. Schiavino D, Nucera E, Zoppi A, Misuraca C, Patriarca G, "Rush desensitization with ubiquinone", Allergy, 1997; 52 (7): 783-4

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.