Rare, IgE-dependent mechanism. Approximately 50% of subjects are atopic.
Sensitisation usually occurs via the digestive tract.
Inhalation of casein is responsible for occupational asthma.
Rhinitis and asthma develop after several years of exposure to the risk.
Skin tests: skin prick tests using commercially available allergens: immunological dosage using RAST/CAP.
Bronchial provocation test (in hospital) is conducted using a solution of 10-50 mg/ml.