Asthma caused by cynorhodon


Occupations
  • Pharmaceutical industry
Agents
Cynorhodon, Dog rose.
 
Incidence
Incidence: probably low since only a few case have been reported and the vitamins industry is very large.
 
Cynorhodon is used in a spray form and therefore the risk is dose dependent.
 
Atopic subjects are more susceptible.
 
IgE-dependent mechanism.
 
Conditions
The ripe hip (fruit) of the dog rose going to seed after flowering is an important source of vitamin C and is used in the pharmaceutical and food industries.
 
Symptoms
Rhinitis and asthma. Urticaria and anaphylactic reactions have been reported.
 
Diagnostic methods
Skin prick test: 0.1 and 1 mg/ml (not commercially available).
 
Immunological assay: ELISA (not commercially available).
 
Bronchial provocation test (in hospital) with an extract at 1/100 m/v.

References

  1. Chest 1985,88:8
  2. J. Allergy Clin. Immunol. 1990,85:704

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.