Asthma caused by hydralazine


Occupations
  • Pharmaceutical industry
Agents
Hydralazine
 
Incidence
Incidence: undetermined - a single case has been described.
 
No immunological mechanism has been reported for this one, atopic subject.
 
Conditions
The symptoms appeared 24 hours after contact with the allergen in the case described.
 
Symptoms
Sporadic coryza, breathing difficulties and asthma.
 
Diagnostic methods
Skin test: negative at 0.1 and 1 mg/ml.
 
Bronchial provocation test (in hospital) produces both immediate and delayed reactions.

References

  1. Thorax 1990, 45:980

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.