Asthma caused by volatile acid chlorides: phenylglycine


Occupations
  • Pharmaceutical industry
Agents
Phenylglycine, Phenylglycine acid chloride.
 
Incidence
Incidence: up to 25% of exposed subjects.
 
30% of affected subjects are atopic.
 
IgE-dependent mechanism.
 
Phenylglycine acid chloride plays the role of an electrophilic hapten.
 
Working in clean conditions (e.g. fume cabinet) almost totally cures this type of asthma.
 
Conditions
Compound used in the synthesis of ampicilline and other betalactamines.
 
Symptoms
Asthma associated with rhinitis and conjunctivitis.
 
Diagnostic methods
Skin tests and bronchial provocation test (in hospital) with some conjugates (phenylglycine-polylysine and human serum albumin) have been performed.

References

  1. J. Allergy Clin. Immunol.1973, 52:73

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.