Several cases have been reported since 1984. Atopy does not appear to be involved. Both immediate and late phase bronchial reactions are observed. In 1991, the first bronchial provocation test using styrene demonstrated that this product was responsible for asthma.
Styrene is a compound required for the manufacture of glass fibre. An atmospheric concentration of 12 ppm of styrene is sufficient to cause a reduction of 20% in FEV1 capacity (TLV 100 ppm).
Tight chest, nocturnal dyspnoea, cough, irritation of the eyes, skin rashes.
No skin tests are available.
Bronchial provocation test (in hospital).