Incidence: only a few cases have been described.
The sensitization delay is always a few months.
Atopy does not play a role.
Only the parent tetracycline molecule seems to cause symptoms.
Classic asthma. There is a risk of anaphylactic reactions and reactivation of symptoms if the drug is taken orally.
Skin tests: IDR from 10-5 fold dilution up to the neat product with a 15 minute period between each test.
Bronchial provocation tests have not been reported, but may be of interest.