Asthma caused by natural dyes
- Cosmetics industry
- Dyeing industry
- Food industry
- Pharmaceutical industry
- Textile industry
Carminic acid, Cochineal, Monascus rubber.
Incidence: very low. Atopy does not play an important role. The mechanism is possibly IgE-dependent.
Sensitization occurs during the fabrication of the colouring agent prepared from the dried Coccus cactus flower and the female cochineal sensitization to Monascus rubber occurs during preparation of asian foods containing colourants (red or yellow). The colouration is derived from the action of the fungus Monascus rubber on Chinese "red rice".
Classical asthma during working hours, as well as rhinitis and conjunctivitis. Ingestion of foodstuffs containing the colouring agent such as red coloured drinks may trigger the illness , and 2 cases of anaphylactic reactions following ingestion of carmin have been reported.
Skin prick tests using the whole dried insect, made into a solution in PBS may be performed, as well as using, carminic acid and cochineal powder.
A specific assay of IgE for RAST has been suggested.
A bronchial provocation test (in hospital) with the suspect allergen is definitive.
For "red rice" and Monascus rubber, skin prick tests have been performed but these are not commercially available. Specific IgEs are not measured routinely, but in the case of carmin, a major allergen has been identified using SDS PAGE (Phadia). Three major allergens have been described, these being carmin, cochineal and carminic acid.