Asthma caused by glyine in the manufacture of salbutamol


Occupations
  • Pharmaceutical industry
Agents
Glycine
 
Incidence
The mechanism remains to be established, but may be due to a beta-blocking or an immunological reaction.
 
Conditions
Glycine is a reagent used in the manufacture of salbutamol.
 
Symptoms
Asthma develops after a long period of exposure to the product. The attacks occur as a late reaction.
 
Diagnostic methods
Bronchial provocation test (in Hospital) by inhalation: 100 mg of glycine in 250 g of lactose.

References

  1. Clin. Allergy 1976, 6:405

As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.